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molossinus

musculus

castaneus

domesticus

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References

Takada et al. 2013, 2015

Related Sites

http://molossinus.nig.ac.jp/msmdb/

MSM/Ms

is an inbred strain established from Japanese wild mice (Mus musculus molossinus) that were collected in Mishima, Shizuoka-ken, Japan in 1978 (Moriwaki et al. 1994, 2009). M. m. molossinus is known to be a hybrid subspecies between M. m. musculus and west European subspecies, M. m. domesticus, from which genomes of the most classical laboratory strains are derived (Yonekawa et al. 1980, 1988; Wade et al. 2002; Yang et al. 2007; Moriwaki 1994; Moriwaki et al 2009). MSM/Ms is chromosomal donor strain in consomic strains (chromosome substitution strains), B6-ChrNMSM (Takada et al. 2008). A large number of QTLs were detected by phenotype screening of the consomic strains (see NIG Mouse Phenotype Database) (Takada et al. 2008).

JF1/Ms

is an inbred strain established from fancy mice found at a pet market in Denmark and transferred to the NIG in 1987, where they were established as an inbred strain in 1993. Morphological and genetic characterization suggested that JF1/Ms is derived from M. m. molossinus (Koide et al. 1998). Resequencing of the whole genome of JF1/Ms revealed that the ancestor of JF1/Ms provided the origin of the M. m. molossinus genome in the classical laboratory strains (Takada et al. 2013).

KJR/Ms

is an inbred strain established from wild mice (Mus musculus musculus) that were collected in Kojuri island, the Republic of Korea in 1984. The founder mice (2 females and 1 male) were transferred to Dr. K. Moriwaki of NIG in the same year.

SWN/Ms

is an inbred strain established from wild mice (Mus musculus musculus) that were collected in the campus of Agricultural College, Suweon, the Republic of Korea in 1984. The founder mice (3 females and 1 male) were gifted from Dr. Cho of Agricultural College to Dr. K. Moriwaki of NIG in the same year.

CHD/Ms

is an inbred strain established from wild mice (Mus musculus musculus) that were collected in Chengdu, China. In 1981, three pairs of the founder mice were transferred to Dr. K. Moriwaki of NIG.

NJL/Ms

is an inbred strain established from wild mice (Mus musculus musculus) that were collected by Dr. J. P. Hjorth of Arhus University in Aarhus, Denmark in 1980. The founder mice (6 females and 4 males) were gifted from Dr. J. P. Hjorth to Dr. K. Moriwaki of NIG in the same year.

BGL2/Ms

is an inbred strain established from wild mice (Mus musculus musculus) that were collected by Dr. F. Bonhomme in General Toshevo, Bulgaria in 1980. Two pairs of the founder mice were gifted from Dr. F. Bonhomme to Dr. K. Moriwaki of NIG in 1981.

HMI/Ms

is an inbred strain established from wild mice (Mus musculus castaneus) that were collected by Dr. M. Sakaizumi of Tokyo Metropolitan Institute of Medical Science in He-mei, Taiwan in 1986. The founder mice (4 females and 3 males) were gifted from Dr. M. Sakaizumi to Dr. K. Moriwaki of NIG in the same year.

BFM/2Ms

is an inbred strain established from wild mice (Mus musculus domesticus) that were collected by Dr. F Bonhomme of University Montpellier in the university campus, Montpellier, France in 1976. Three pairs of the founder mice were gifted from Dr. F. Bonhomme to Dr. K. Moriwaki of NIG in 1980.

PGN2/Ms

is an inbred strain established from wild mice (Mus musculus domesticus) that were collected by Dr. P. Michael in a farm in Windsor, Ontario, Canada in 1978. The founder mice (3 females and 2 males) were gifted from Dr. P. Michael to Dr. K. Moriwaki of NIG in 1979.

Mishima Battery

The laboratory mouse is one of the most important bioresources for studying principles underlying higher-order biological phenomena and etiologies of human diseases.

National Institute of Genetics (NIG) has established a series of mouse experimental strains named "Mishima Battery" since 1970's. It consists of ten inbred strains originated from three or four subspecies of Mus musculus, which are genetically remote from one another and widely distributed in the world.

Because of the large genetic divergence, mice in “Mishima Battery”. These strains have very remote genetic status from the commonly used laboratory mouse strains such as C57BL/6J, and show very unique phenotypes that are not observed in commonly used laboratory mouse strains including C57BL/6J.

The mouse strains in "Mishima Battery" are now provided distributed to the science research community, and contribute to a broad range of life science.